Bouvy, M.D., Ph.D., Patrick Schrauwen, Ph.D., and G.J. Jaap Teule, M.D., Ph.D.: Cold-Activated Dark brown Adipose Cells in Healthy Men There is evidence that stimulating adaptive thermogenesis, thought as the facultative heat stated in response to cold and diet, might serve as a means of preventing or treating obesity1; thus, it really is of interest to understand the mechanisms underlying adaptive thermogenesis. We previously reported that cold-induced thermogenesis in the lack of shivering accounts for an average of 11.8 percent of the resting metabolic process, with high individual variation.2 Individual differences in energy expenditure can possess large, long-term effects on bodyweight.3 Several prospective research have shown that a relatively low energy expenditure predicts a gain in body weight.4,5 Hence, adaptive thermogenesis may be an attractive target for antiobesity therapies.As of March 31, 2010, the Company’s cash, cash equivalents, investments and settlement rights connected with certain auction price securities totaled $283.0 million. Furthermore, AMAG received the $60 million upfront payment from Takeda in April 2010, which can be therefore not contained in the Company’s cash balance by March 31, 2010. Revenues for the one fourth ended March 31, 2010 were $13.3 million in comparison with revenues of $1.0 million for the same period in 2009 2009.