Genomic DNA was captured on exomes with the use of the Sequence Capture Individual Exome 2.1M Array . The captured libraries were sequenced on the Illumina Genome Analyzer, and image analysis and base calling had been performed. The resulting sequence data were processed with the use of MAQ22 software. SAMtools software was used to identify single-nucleotide variants. The raw output was further filtered, as explained previously, to remove common variants reported in reference genomes.23 Filters were also applied against published databases. Variants were annotated based on the effect on the proteins, novelty, conservation, and cells expression by using an automated pipeline for genome annotation.19 A novel variant was recognized in DYRK1B, the gene encoding dual-specificity tyrosine-phosphorylation-regulated kinase 1B.As a total result, Crohn’s is frequently dismissed and overlooked. By talking with others about the daily challenges I must face, it not merely allows them to comprehend my barriers, but it helps me beat them, as well.’ Related StoriesRheumatoid arthritis considerably increases threat of death due to cardiovascular causesNovel modular partial wrist implant might provide relief for sufferers with unpleasant wrist arthritisImmune system protein has potential to prevent onset of aggressive form of rheumatoid arthritisScholarship recipients were chosen by an independent selection committee of leading physicians, nurses and patient representatives from across Canada.