Maria Margollicci.

Alice Luddi, Ph pfizer .D., Maria Margollicci, Ph.D., Laura Gambera, Ph.D., Francesca Serafini, Ph.D., Maddalena Cioni, M.D., Vincenzo De Leo, M.D., Paolo Balestri, M.D., and Paola Piomboni, Ph.D.: Brief Statement: Spermatogenesis in a Man with Complete Deletion of USP9Y Deletions of the distal euchromatic region of the Y chromosome are connected with spermatogenic failure.1 The locus, named azoospermia element , extends from the proximal to the distal end of the q region of the Y chromosome2 possesses three regions: AZFa, AZFb, and AZFc.5 USP9Y spans 170 kb of DNA, consists of at least 46 exons, and occupies a small portion of the AZFa interval.

In humans, brown adipose tissue is found in infants and small children primarily, and it has been considered to be essentially nonexistent and without physiologic relevance in adults.10 However, estimates claim that if it were present, less than 50 g of maximally stimulated brown adipose tissue could account for up to 20 percent of daily energy expenditure in an adult human.11 Despite its potential physiologic importance, solutions to gauge the activity and mass of brown adipose tissue in human beings have been lacking. Methods Patients This study followed institutional guidelines and was approved by the ethics committees of Beth Israel Deaconess Medical Center and Partners HealthCare, in Boston.