Safety End Points The main safety end point of moderate or heavy bleeding occurred in 438 patients in the vorapaxar group, as compared with 267 patients in the placebo group . There was no proof heterogeneity in the effect of vorapaxar on moderate or heavy bleeding in major subgroups . Rates of TIMI clinically severe bleeding and prices of TIMI main bleeding not linked to coronary-artery bypass grafting had been also both significantly improved in the vorapaxar group in comparison with the placebo group . General, intracranial hemorrhage occurred in 102 individuals in the vorapaxar group, as compared with 53 patients in the placebo group . Fatal bleeding occurred in 29 patients in the vorapaxar group, as compared with 20 patients in the placebo group .6 Simple Communication Stress Busters for a Healthy Heart If heart disease run in your loved ones, or if your doctor has indicated that you should take steps to safeguard your center from progressive disease, among the plain things you will want to do is reduce the amount of stress in your life. This can be done in lots of ways, and results will change from one person to another. Overall, though, you may want to consider some of the strategies detailed below to ease tension and improve your sense of well being.