Perkins, M.D.: Fast Molecular Recognition of Tuberculosis and Rifampin Level of resistance Only a part of the estimated 500,000 patients who have multidrug-resistant tuberculosis and 1.37 million patients who have coinfection with tuberculosis and the human immunodeficiency virus worldwide each year have access to sufficiently sensitive case recognition or drug-susceptibility testing.1 Diagnostic delay, aggravated by the disproportionate frequency of smear-adverse disease in HIV-associated tuberculosis, is common.2-5 The failure to quickly recognize and treat affected patients results in increased mortality, secondary resistance , and ongoing transmission.For example, in 2005 about 22 million Americans received health care for osteoarthritis and related circumstances, 49 million for asthma or chronic obstructive pulmonary disease, 17 million for diabetes, 45 million for high blood circulation pressure, and 19 million for cardiovascular disease, according to AHRQ. On the subject of 77 % of Us citizens aged 65 and older had several chronic conditions. Only 14 % of these 18 to 34 experienced two or more conditions. Nine of every 10 dollars spent for medical care on adults in the usa was spent to take care of persons with chronic conditions. AHRQ, which is part of the U.S.