One of is own previous studies showed chronic pain sufferers lose gray matter volume over time. Chronic pain is among the most expensive health care conditions in the U.S. And takes an enormous toll on quality of life, yet there isn’t a scientifically validated therapy for the condition still. Lower back pain represents 28 % of most causes of pain in the U.S.; about 23 % of these patients suffer long-term discomfort. An interview with Professor Lesley Jones The abnormalities identified in the analysis were found in multiple white matter axon bundles, some encircling the nucleus accumbens and medial prefrontal cortex, two brain areas involved in processing discomfort and emotion. Last year, the Apkarian group demonstrated that the physiological properties of these two regions identify which individuals will persist with back again pain.Lorch, M.D.: Brief Record: Response and Acquired Level of resistance to Everolimus in Anaplastic Thyroid Cancer A better knowledge of the mechanisms of sensitivity and level of resistance to anticancer therapies may improve patient selection and allow the advancement of rational treatment designs. One approach involves learning paired biopsy samples of pretreatment and drug-resistant tumors attained from patients with exquisite sensitivity or unusually durable responses to therapy. Tumors that exhibit a dependency on the mTOR pathway may have enhanced sensitivity to mTOR inhibition.