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Additionally, slight to moderate gastrointestinal adverse events have been the most commonly reported side-effect to date for patients at these high doses of lomitapide. Only two of the 14 sufferers experienced transaminase elevations which needed a dosage reduction and non-e of the individuals required drug discontinuation due to liver function test elevations. Related StoriesDisclosing genetic risk for CHD results in lower low-density lipoprotein cholesterolUnderstanding how schizophrenia impacts workings of the brainSt. We were incredibly encouraged to find that treatment with lomitapide is usually associated with minimal to moderate hepatic fat accumulation at 26 weeks that appears to stabilize or actually decrease after twelve months of treatment.But only 3 % of unexposed veterans had developed MGUS. The analysis also revealed that Operation Ranch Hand veterans were more likely to have higher degrees of TCDD in their blood, and that their threat of MGUS increased as their TCDD amounts increased. There exists a dose-response relationship, Landgren said. Munshi said the full total results provide strong evidence of a link between Agent Orange and multiple myeloma, although a primary cause-and-effect relationship can’t be determined in this sort of observational study. It’s not proof, but it’s a good link to show there’s a connection, said Munshi, who wrote an accompanying editorial to the scholarly research. The findings were published online Sept.